GMDS Antibody
Rabbit Polyclonal
Catalog number: 15442-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IP, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | HeLa cells |
| Positive IHC detected in | human lymphoma |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HeLa cells were subjected to SDS PAGE followed by western blot with 15442-1-AP(GMDS Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lymphoma using 15442-1-AP(GMDS Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lymphoma using 15442-1-AP(GMDS Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | GMDS fusion protein ag7319 | Full name | GDP-mannose 4,6-dehydratase |
|
Calculated molecular weight |
42kd |
Observed molecular
weight |
40-42kd |
|
GenBank accession number |
BC000117 | Gene ID (NCBI) | 2762 |
| Gene symbol | GMDS | Synonyms | GMD; SDR3E1 |
Background
GDP-D-mannose-4,6-dehydratase (GMDS) is the key enzyme in the ‘de novo’ pathway of GDP-L-fucose biosynthesis(PMID:10462046). The enzyme is also named as GMD and belongs to the GDP-mannose 4,6-dehydratase family. The gene encodes a 42 kDa protein that catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. This antibody is specific to GMDS. |
