Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each
of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a
linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.Linker histones are
involved in the formation of higher order structure in chromatin and the maintenance of overall chromatin compaction. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell
division.Histone H1.0 (H1F0,H1FV) is a linker histone that is widely expressed in many tissues and almost all vertebrates,
unlike some other linker histones. The observed molecular weight of H1F0 is about 32 kDa.