HCN2 Antibody
Rabbit Polyclonal
Catalog number: 55245-1-AP
Ask a question about this product click here
Loading price...
Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | mouse brain tissue, Jurkat cells |
| Positive IHC detected in | human heart |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with 55245-1-AP(HCN2 Antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human heart using 55245-1-AP(HCN2 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human heart using 55245-1-AP(HCN2 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
|
Calculated molecular weight |
97kd |
Observed molecular
weight |
97-110kd |
|
GenBank accession number |
NM_001194 | Gene ID (NCBI) | 610 |
| Gene symbol | HCN2 | Synonyms | BCNG-2; BCNG2; HAC-1 |
Background
HCN2, also named as BCNG2, belongs to the potassium channel HCN family. It hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). HCN2 produces a large instantaneous current. It is activated by cAMP. HCN2 is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. This antibody is specific to HCN2. |
