IFT88 (intraflagellar transport protein 88), also known as TG737 or TTC10 (TPR repeat protein 10), is involved in primary cilium biogenesis. Cilia are organelles that play diverse roles, from fluid movement to sensory reception. Mutations in IFT88/Tg737 of mouse cause a wide spectrum of phenotypes, including random left-right axis specification, polycystic kidney disease, liver and pancreatic defects, hydrocephalus, and skeletal patterning abnormalities. IFT88 also play important roles in assembly and maintenance of photoreceptor outer segment. Additionally, IFT88 is thought to function as a centrosomal protein that may regulate the G1 to S phase cell cycle transition in non-ciliated cells.IFT88 is required for spindle orientation in mitosis, the depletion of IFT88 induces mitotic defects in human cultured cells. This antibody was raised against the C-terminal region of human IFT88 and can detect the endogenous level of IFT88.