IGFBP1 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human; other species not tested. |
| Cited species | |
| Positive WB detected in | human placenta tissue |
| Recommended dilution | WB: 1:200-1:1000 |
IP = Immunoprecipitation
human placenta tissue were subjected to SDS PAGE followed by western blot with 13981-1-AP(IGFBP1 Antibody) at dilution of 1:300
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | IGFBP1 fusion protein ag5026 | Full name | insulin-like growth factor binding protein 1 |
|
Calculated molecular weight |
28kd |
Observed molecular
weight |
35kd |
|
GenBank accession number |
BC057806 | Gene ID (NCBI) | 3484 |
| Gene symbol | IGFBP1 | Synonyms | AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1 |
Insulin-like growth factor (IGF)-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome. |
