IMPDH2 Antibody
Rabbit Polyclonal
Catalog number: 12948-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IF, IP |
| Cited applications | IF, IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | human heart tissue, A549 cells, human brain tissue, K-562 cells, mouse heart tissue, mouse lung tissue |
| Positive IHC detected in | human lung cancer |
| Positive IF detected in | Hela cells |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 IF: 1:20-1:50 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of anti-IMPDH2 (12948-1-AP for IP and Detection) with K562 cell lysate.
human heart tissue were subjected to SDS PAGE followed by western blot with 12948-1-AP(IMPDH2 Antibody) at dilution of 1:1600
Immunohistochemistry of paraffin-embedded human lung cancer using 12948-1-AP(IMPDH2 Antibody) at Dilution 1:100 (under 10x lens)
Immunofluorescent analysis of Hela cells, using IMPDH2 antibody 12948-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | IMPDH2 fusion protein ag3632 | Full name | IMP (inosine monophosphate) dehydrogenase 2 |
|
Calculated molecular weight |
514aa,56kd |
Observed molecular
weight |
56kd |
|
GenBank accession number |
BC012840 | Gene ID (NCBI) | 3615 |
| Gene symbol | IMPDH2 | Synonyms | IMPD2; IMPDH-II |
Background
IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270) IMPDH2 is highly enriched in RR(filamentous rods and rings).This antibody is specific to IMPDH2. |
