IMPDH2 AntibodyRabbit Polyclonal
|Tested applications||ELISA, WB, IHC, IF, IP|
|Cited applications||IF, IHC, WB|
|Species specificity||human, mouse, rat; other species not tested.|
|Positive WB detected in||human heart tissue, A549 cells, human brain tissue, K-562 cells, mouse heart tissue, mouse lung tissue|
|Positive IHC detected in||human lung cancer|
|Positive IF detected in||Hela cells|
|Recommended dilution||WB: 1:500-1:5000|
IP = Immunoprecipitation
- IP result of anti-IMPDH2 (12948-1-AP for IP and Detection) with K562 cell lysate.
- human heart tissue were subjected to SDS PAGE followed by western blot with 12948-1-AP(IMPDH2 Antibody) at dilution of 1:1600
- Immunohistochemistry of paraffin-embedded human lung cancer using 12948-1-AP(IMPDH2 Antibody) at Dilution 1:100 (under 10x lens)
- Immunofluorescent analysis of Hela cells, using IMPDH2 antibody 12948-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
|Source||Rabbit||Purification method||Antigen affinity purification|
|Isotype||IgG||Storage||PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.|
|Immunogen||IMPDH2 fusion protein ag3632||Full name||IMP (inosine monophosphate) dehydrogenase 2|
|BC012840||Gene ID (NCBI)||3615|
|Gene symbol||IMPDH2||Synonyms||IMPD2; IMPDH-II|
IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270) IMPDH2 is highly enriched in RR(filamentous rods and rings).This antibody is specific to IMPDH2.
|ag17170||IMPDH2 fusion protein 6*his tag|
|ag17296||IMPDH2 fusion protein gst tag|
|ag17637||IMPDH2 fusion protein 6*his tag|
|ag3632||IMPDH2 fusion protein gst tag|