IRF8 Antibody
Rabbit Polyclonal
Catalog number: 18977-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse; other species not tested. |
| Cited species | |
| Positive WB detected in | mouse spleen tissue |
| Positive IHC detected in | human lymphoma |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse spleen tissue were subjected to SDS PAGE followed by western blot with 18977-1-AP(IRF8 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lymphoma using 18977-1-AP(IRF8 Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lymphoma using 18977-1-AP(IRF8 Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | interferon regulatory factor 8 |
|
Calculated molecular weight |
48kd |
Observed molecular
weight |
48kd |
|
GenBank accession number |
NM_002163 | Gene ID (NCBI) | 3394 |
| Gene symbol | IRF8 | Synonyms | H-ICSBP; ICSBP; ICSBP1; IRF-8 |
Background
IRF8 also named as ICSBP1, is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). It plays a negative regulatory role in cells of the immune system. It is predominantly in lymphoid tissues. |
