LAMP3 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | mouse lung tissue, A375 cells, A549 cells, mouse thymus tissue, rat lung tissue |
| Positive IHC detected in | human lung |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:20-1:200 |
IP = Immunoprecipitation
mouse lung tissue were subjected to SDS PAGE followed by western blot with 12632-1-AP(LAMP3 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung using 12632-1-AP(LAMP3 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lung using 12632-1-AP(LAMP3 Antibody) at Dilution 1:50 (under 40x lens)
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | LAMP3 fusion protein ag3325 | Full name | lysosomal-associated membrane protein 3 |
|
Calculated molecular weight |
416aa,44kd |
Observed molecular
weight |
70 kDa |
|
GenBank accession number |
BC032940 | Gene ID (NCBI) | 27074 |
| Gene symbol | LAMP3 | Synonyms | CD208; DC-LAMP; DCLAMP; LAMP; TSC403 |
LAMP3 (lysosome-associated membrane protein 3), also known as DC-LAMP (DC-lysosome-associated membrane glycoprotein), TSC403 or CD208, is a highly glycosylated lysosomal membrane protein that belongs to the LAMP family. The mature glycoprotein has an apparent molecular mass of 70-90 kDa, which is considerably larger than its predicted mass of 44 kDa (PMID: 9768752). LAMP3 is expressed in lung type II pneumocytes, lymphoid organs and dendritic cells. It might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. LAMP3 mRNA is up-regulated in some human cancers (PMID:9721848). LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer (PMID: 16204031). |
