LGALS3BP Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IP |
| Cited applications | IHC, WB |
| Species specificity | human; other species not tested. |
| Cited species | human |
| Positive WB detected in | COLO 320 cells, HEK-293 cells, HeLa cells |
| Recommended dilution | WB: 1:200-1:2000 |
IP = Immunoprecipitation
IP result of anti-LGALS3BP(10281-1-AP for IP and Detection).
COLO 320 cells were subjected to SDS PAGE followed by western blot with 10281-1-AP(LGALS3BP Antibody) at dilution of 1:600
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | LGALS3BP fusion protein ag0294 | Full name | lectin, galactoside-binding, soluble, 3 binding protein |
|
Calculated molecular weight |
585aa,65kd |
Observed molecular
weight |
65kd |
|
GenBank accession number |
BC002403 | Gene ID (NCBI) | 3959 |
| Gene symbol | LGALS3BP | Synonyms | 90K; BTBD17B; MAC-2-BP |
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP is a widely expressed, secreted galectin. It has been found elevated in the serum of patients with various types of breast, lung, colorectal, ovary, and endometrial cancer, and in those infected by the human immunodeficiency virus (HIV). High expression levels of LGALS3BP are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Immunoblotting showed that LGALS3BP is likely contained in breast milk, serum, semen, saliva, urine, and tears. |
