TAU Antibody
Rabbit Polyclonal
Catalog number: 10274-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | HT-1080 cells, HeLa cells, mouse brain tissue, rat brain tissue, SH-SY5Y cells |
| Recommended dilution | WB: 1:200-1:2000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HT-1080 cells were subjected to SDS PAGE followed by western blot with 10274-1-AP(TAU Antibody) at dilution of 1:600
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | TAU fusion protein ag0354 | Full name | microtubule-associated protein tau |
|
Calculated molecular weight |
79kd |
Observed molecular
weight |
68 kDa, 81 kDa,100 kDa |
|
GenBank accession number |
BC000558 | Gene ID (NCBI) | 4137 |
| Gene symbol | MAPT | Synonyms | DDPAC; FLJ31424; FTDP-17; MAPTL; MGC138549; MSTD; MTBT1; MTBT2; PPND; TAU |
Background
The microtubule-associated protein TAU (MAPT or TAU) is encoded by MAPT gene, which locates on human chromosome 17q21, binds to the tubulin subunit of microtubule and promotes its assembly and stability. Most TAU is expressed in neurons, and TAU isoform is expressed in the peripheral nervous system while the others are expressed in the central nervous system. TAU links axonal microtubules with C-terminus to neural plasma membrane components with its N-terminus, suggesting the participation in intracellular signal transduction and neuron's development and viability. Present polyclonal anti-MAPT antibody was produced by immunizing animals with N-terminal of MAPT and can detect approx 70-kDa and 100-kDa bands in brain tissues. |
