MCRS1 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | HeLa cells, human brain tissue, human liver tissue, human spleen tissue, Jurkat cells, mouse spleen tissue, mouse uterus tissue |
| Recommended dilution | WB: 1:500-1:5000 |
IP = Immunoprecipitation
HeLa cells were subjected to SDS PAGE followed by western blot with 11362-1-AP(MCRS1 Antibody) at dilution of 1:1000
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | MCRS1 fusion protein ag1904 | Full name | microspherule protein 1 |
|
Calculated molecular weight |
51kd |
Observed molecular
weight |
55kd |
|
GenBank accession number |
BC011794 | Gene ID (NCBI) | 10445 |
| Gene symbol | MCRS1 | Synonyms | ICP22BP; INO80Q; MCRS2; MSP58; P78 |
MCRS1, also named INO80Q, MSP58 or p78, is a nucleolar protein expressed in the very early S phase. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. MCRS1 is also present on polyribosomes of synaptoneurosome as a novel RNA-binding protein to activate the rRNA transcription. The forkhead-associated domain of MCRS1 is involved in association with centrosomal protein Nde1, comprising a component of the centrosome and taking an essential role in viability. Its isoform MCRS2 might be a linker between telomere maintenance and cell-cycle regulation by interacting with LPTS/PinX1, a telomerase-inhibitory protein. MCRS1 is detected by Western blot as a highly modified protein at 78 kDa and minor bands at about 62 and 55 kDa. |
