MPV17 Antibody
Rabbit Polyclonal
Catalog number: 10310-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IF, WB |
| Species specificity | human, mouse; other species not tested. |
| Cited species | human |
| Positive WB detected in | mouse kidney tissue, human brain tissue, human heart tissue, human liver tissue, human placenta tissue, mouse heart tissue |
| Positive IHC detected in | human pancreas cancer |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10310-1-AP(MPV17 Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using 10310-1-AP(MPV17 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human pancreas cancer using 10310-1-AP(MPV17 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | MPV17 fusion protein ag0312 | Full name | MpV17 mitochondrial inner membrane protein |
|
Calculated molecular weight |
20 kDa |
Observed molecular
weight |
20kd |
|
GenBank accession number |
BC001115 | Gene ID (NCBI) | 4358 |
| Gene symbol | MPV17 | Synonyms | SYM1 |
Background
MPV17, also termed as SYM1, encodes an inner mitochondrial membrane protein. It’s potential candidate that may account for the mitochondrial (mt) DNA depletion syndromes (MDDS) characterized by a severe, tissue-specific decrease of mtDNA copy number and ultimate organ failure. It’s a human ortholog of the mouse kidney disease gene Mpv17. Absence or malfunction of MPV17 causes oxidative phosphorylation (OXPHOS) failure and mtDNA depletion, not only in affected individuals but also in Mpv17-/- mice. MPV17 contribute to ROS homeostasis, but the downstream signaling is unknown yet. Catalog# 10310-1-AP is a rabbit polyclonal antibody raised against the full-length of human MPV17. |
