MPZ,P0 AntibodyRabbit Polyclonal
|Tested applications||ELISA, WB, IF|
|Cited applications||IF, WB|
|Species specificity||human, mouse, rat; other species not tested.|
|Cited species||mouse, rat|
IP = Immunoprecipitation
- WB result from Chattopadhyay S (PMID:19229995); Schwann cell differentiation was induced with dbcAMP (500 μM) for 48 h, followed by treatment with rhMMP-9 (100 nM) for 15 min. A, rhMMP-9 stimulates transient ERK1/2 activation over a 1 h period. Successful Schwann cell differentiation was confirmed by myelin protein zero (P0) expression, β-actin was used as loading control.
- IF result from Huaqing Liu (PMID:20448483);Dual immunofluorescence for BrdU (red) with phenotypic cell markers (green) in distal segments of MMPi-treated promotes Schwann cell (SC) mitosis in regenerating nerves. myelinating SCs (mSCs) (P0)
|Source||Rabbit||Purification method||Antigen affinity purification|
|Isotype||IgG||Storage||PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.|
|Immunogen||MPZ,P0 fusion protein ag0848||Full name||myelin protein zero|
|BC006491||Gene ID (NCBI)||4359|
|Gene symbol||MPZ||Synonyms||CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0|
MPZ (myelin protein zero), also known as P0, a transmembrane glycoprotein (~30 kDa), is a member of the immunoglobulin supergene family. Synthesized by myelin-forming Schwann cells, MPZ is the major structural protein component of myelin in the peripheral nervous system. It is involved in formation and maintenance of compact myelin, and plays a role in the creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. More than 120 mutations detected in the gene of MPZ cause various forms of hereditary neuropathy, which include Charcot-Marie-Tooth disease type 1B (CMT1B), CMT2, Dejerine-Sottas syndrome (DSS), and congenital hypomyelination neuropathy (CHN). This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.