MTM1 Antibody
Rabbit Polyclonal
Catalog number: 13924-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | L02 cells, Jurkat cells |
| Positive IHC detected in | human osteosarcoma |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
L02 cells were subjected to SDS PAGE followed by western blot with 13924-1-AP(MTM1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human osteosarcoma using 13924-1-AP(MTM1 Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human osteosarcoma using 13924-1-AP(MTM1 Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | MTM1 fusion protein ag4940 | Full name | myotubularin 1 |
|
Calculated molecular weight |
70kd |
Observed molecular
weight |
63kd |
|
GenBank accession number |
BC030779 | Gene ID (NCBI) | 4534 |
| Gene symbol | MTM1 | Synonyms | CNM; MTMX; XLMTM |
Background
The MTM1(Myotubularin) gene encodes a protein that belongs to a family of putative tyrosine phosphatases. It is required for muscle cell differentiation. The protein is also a potent phosphatidylinositol 3-phosphate (PI3P) phosphatase, which is a 66 kDa ubiquitous protein that is found mutated in the X-linked genetic disorder myotubular myopathy(XLMTM).MTM1 could therefore act as a regulator of the highly active phosphoinositide (PI) metabolism in cells, where interconversions of the eight PIs described so far is controlled by a set of specific kinases and phosphatases(PMID:14660569). This antibody is specific to MTM1. |
