MYST2 Antibody
Rabbit Polyclonal
Catalog number: 13751-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | NIH/3T3 cells, HeLa cells, Jurkat cells, MCF7 cells, PC-3 cells, human testis tissue |
| Positive IHC detected in | human ovary tumor |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 13751-1-AP(MYST2 Antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human ovary tumor using 13751-1-AP(MYST2 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human ovary tumor using 13751-1-AP(MYST2 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | MYST2 fusion protein ag4693 | Full name | MYST histone acetyltransferase 2 |
|
Calculated molecular weight |
611aa,71kd |
Observed molecular
weight |
83kd |
|
GenBank accession number |
BC032640 | Gene ID (NCBI) | 11143 |
| Gene symbol | MYST2 | Synonyms | HBO1; HBOA; KAT7 |
Background
MYST2, also named as HBO1, HBOa MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, belongs to the MYST (SAS/MOZ) family. It specifically represses AR mediated transcription. MYST2 is a candidate oncogene. It enhances the anchorage-independent growth of breast cancer cells.(PMID:19372580) MYST2 is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. It is an important downstream molecule of ERa, and ERK1/2 signaling pathway may involved in the expression of HBO1 increased by E2. |
