NUMB Antibody
Mouse Monoclonal
Catalog number: 60137-1-Ig
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Applications
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human; other species not tested. |
| Cited species | |
| Positive WB detected in | Human brain, mouse brain tissue |
| Recommended dilution | WB: 1:200-1:1000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Human brain were subjected to SDS PAGE followed by western blot with 60137-1-Ig(NUMB Antibody) at dilution of 1:300
Product Information
| Source | Mouse | Purification method | Caprylic acid/ammonium sulfate precipitation |
| Isotype | IgG2a | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | peptide | Full name | numb homolog (Drosophila) |
|
Calculated molecular weight |
71kd |
Observed molecular
weight |
66-72kd |
|
GenBank accession number |
BC068476 | Gene ID (NCBI) | 8650 |
| Gene symbol | NUMB | Synonyms | S171 |
Background
NUMB, also named as S171, plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71 and P72, can’t recognize the NUMBL. |
