OAS1 Antibody
Rabbit Polyclonal
Catalog number: 14955-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HeLa cells, mouse brain tissue |
| Positive IHC detected in | human liver |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HeLa cells were subjected to SDS PAGE followed by western blot with 14955-1-AP(OAS1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver using 14955-1-AP(OAS1 Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver using 14955-1-AP(OAS1 Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | OAS1 fusion protein ag6793 | Full name | 2',5'-oligoadenylate synthetase 1, 40/46kDa |
|
Calculated molecular weight |
46kd |
Observed molecular
weight |
48kd,100kd |
|
GenBank accession number |
BC000562 | Gene ID (NCBI) | 4938 |
| Gene symbol | OAS1 | Synonyms | IFI-4; OIAS; OIASI |
Background
The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS1, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS1 (type I enzymes) have molecular weights of 42, 44, 46, and 48 kDa, form tetramers, and contain a single consensus sequence(PMID:12590567). OAS1 is a strong candidate for determining susceptibility or resistance to viral infections(PMID:15732009). This antibody is specific to OAS1. |
