OBFC2A Antibody
Rabbit Polyclonal
Catalog number: 16719-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | mouse |
| Positive WB detected in | COLO 320 cells |
| Recommended dilution | WB: 1:200-1:2000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
COLO 320 cells were subjected to SDS PAGE followed by western blot with 16719-1-AP(OBFC2A Antibody) at dilution of 1:600
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | OBFC2A fusion protein ag10158 | Full name | oligonucleotide/oligosaccharide-binding fold containing 2A |
|
Calculated molecular weight |
124aa,14kd |
Observed molecular
weight |
22kd |
|
GenBank accession number |
BC107723 | Gene ID (NCBI) | 64859 |
| Gene symbol | OBFC2A | Synonyms | DKFZp667M1322; FLJ13624; FLJ22833; MGC111163; SSB2 |
Background
Single-stranded DNA (ssDNA)-binding proteins (SSBs) are ubiquitous and essential for a variety of DNA metabolic processes, including recombination, replication, and detection and repair of damage. SSBs have multiple roles in binding and sequestering ssDNA, detecting DNA damage, stimulating nucleases, helicases and strand-exchange proteins, activating transcription and mediating protein-protein interactions [PMID:18449195] Human single-stranded DNA-binding protein 1 (hSSB1), encoded by OBFC2B, is characterized as an essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic stability [PMID:22940690]. |
