ORAI1 Antibody
Rabbit Polyclonal
Catalog number: 13130-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | IF, WB |
| Species specificity | human, mouse, rat, zebrafish; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | Jurkat cells, A375 cells, MCF7 cells, mouse ovary tissue, mouse spleen tissue, PC-3 cells |
| Recommended dilution | WB: 1:200-1:2000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Jurkat cells were subjected to SDS PAGE followed by western blot with 13130-1-AP(ORAI1 Antibody) at dilution of 1:800
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | ORAI1 fusion protein ag3758 | Full name | ORAI calcium release-activated calcium modulator 1 |
|
Calculated molecular weight |
301aa,33kd |
Observed molecular
weight |
45-47kd |
|
GenBank accession number |
BC015369 | Gene ID (NCBI) | 84876 |
| Gene symbol | ORAI1 | Synonyms | CRACM1; FLJ14466; ORAT1; TMEM142A |
Background
Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a 35-45 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene. |
