PANK2 AntibodyRabbit Polyclonal
|Tested applications||ELISA, WB, IHC, IP|
|Species specificity||human, mouse, rat; other species not tested.|
|Positive WB detected in||HeLa cells, HepG2 cells, human brain tissue, mouse brain tissue, mouse lung tissue|
|Positive IHC detected in||human lung cancer|
|Recommended dilution||WB: 1:200-1:2000|
IP = Immunoprecipitation
- IP result of anti-PANK2 (11001-1-AP for IP and Detection) with mouse brain tissue lysate.
- HeLa cells were subjected to SDS PAGE followed by western blot with 11001-1-AP(PANK2 Antibody) at dilution of 1:600
- Immunohistochemistry of paraffin-embedded human lung cancer using 11001-1-AP(PANK2 Antibody) at Dilution 1:10 (under 10x lens)
|Source||Rabbit||Purification method||Antigen affinity purification|
|Isotype||IgG||Storage||PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.|
|Immunogen||PANK2 fusion protein ag1413||Full name||pantothenate kinase 2|
|BC009421||Gene ID (NCBI)||80025|
|Gene symbol||PANK2||Synonyms||C20orf48; FLJ17232; HARP; HSS; MGC15053; NBIA1; PKAN|
Pantothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis. PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other abnormalities(PMID:20603201). PanK2 protein is localized to mitochondria of neurons in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-targeting sequences(PMID:15659606 ). It has 4 isoforms produced by alternative splicing and alternative initiation. This antibody is specific to PANK2.