PANK2 Antibody
Rabbit Polyclonal
Catalog number: 11001-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HeLa cells, HepG2 cells, human brain tissue, mouse brain tissue, mouse lung tissue |
| Positive IHC detected in | human lung cancer |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:10-1:100 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of anti-PANK2 (11001-1-AP for IP and Detection) with mouse brain tissue lysate.
HeLa cells were subjected to SDS PAGE followed by western blot with 11001-1-AP(PANK2 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human lung cancer using 11001-1-AP(PANK2 Antibody) at Dilution 1:10 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | PANK2 fusion protein ag1413 | Full name | pantothenate kinase 2 |
|
Calculated molecular weight |
63kd |
Observed molecular
weight |
59kd,48kd |
|
GenBank accession number |
BC009421 | Gene ID (NCBI) | 80025 |
| Gene symbol | PANK2 | Synonyms | C20orf48; FLJ17232; HARP; HSS; MGC15053; NBIA1; PKAN |
Background
Pantothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis. PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other abnormalities(PMID:20603201). PanK2 protein is localized to mitochondria of neurons in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-targeting sequences(PMID:15659606 ). It has 4 isoforms produced by alternative splicing and alternative initiation. This antibody is specific to PANK2. |
