PDE4C Antibody
Rabbit Polyclonal
Catalog number: 21754-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | PDE4C fusion protein ag16130 | Full name | phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) |
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Calculated molecular weight |
712aa,80kd |
Observed molecular
weight |
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GenBank accession number |
BC109067 | Gene ID (NCBI) | 5143 |
| Gene symbol | PDE4C | Synonyms | DPDE1; MGC126222 |
Background
PDE4C(cAMP-specific 3',5'-cyclic phosphodiesterase 4C) is also named as DPDE1 and belongs to the PDE4 subfamily, which play a key role in lung inflammation and hyperresponsiveness. PDE4C promotes the hydrolysis of cAMP, and PKD2, functioningas a Ca2+ entry channel, may mediate local accumulation of Ca2+ that inhibits the activity of Ca2+-sensitive ADCY5(PMID:21670265). The three isoforms(84,75, and 64 kDa) of PDE4C have been detected in cytosolic, microsomal, and nuclear(PMID:21784969). This antibody is specific to PDE4C. |
