PDIA3 Antibody
Rabbit PolyClonal
Catalog No.: 15967-1-AP
Ask question about this product? click here
Loading price...
This product is not available.
Applications
| Tested Applications: | ELISA,WB,IHC,IF |
| Specificity Reaction: | Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Positive WB detected In: | Human liver |
| Positive IHC detected In: | Lung cancer |
| Positive IF detected In: | HepG2 |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Human liver were subjected to SDS PAGE followed by western blot with 15967-1-AP(PDIA3 Antibody) at dilution of 1:1200
Immunohistochemistry of paraffin-embedded Lung cancer using 15967-1-AP(PDIA3 Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded Lung cancer using 15967-1-AP(PDIA3 Antibody) at Dilution 1:100 (under 40x lens)
Immunofluorescent analysis of HepG2 cells, using PDIA3 antibody 15967-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Product Information
| Source: | Rabbit | Purify: | Antigen Affinity purified |
| IsoType: | IgG | Storage: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | PDIA3 fusion protein ag8741 | Full Name: | protein disulfide isomerase family A, member 3 |
|
Caculated Molecular Weight: |
505aa,57kd |
Observed Molecular
Weight: |
57kd |
| GenbankNo | BC014433 | GeneID: | 2923 |
| Symbol | PDIA3 | Synonyms | PDIA3;ER60;ERp57;ERp60;ERp61;GRP57;GRP58;HsT17083;P58;PI-PLC ; |
Background
PDIA3, also named as P58, ER60, ERp57, ERp60, ERp61, GRP57, GRP58 and PI-PLC, is a member of the PDI family, participates in the oxidation, reduction, and isomerization of disulfide bonds for correct folding of secretory proteins before modification and transport in the endoplasmic reticulum. It is associated with apoptosis or inhibition of cancer cell growth. PDIA3 was once thought to be a phospholipase; however, it has been demonstrated that this protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. |
