PGRMC1 Antibody
Rabbit Polyclonal
Catalog number: 12990-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | HEK-293 cells, HepG2 cells, human brain tissue, human liver tissue, MCF7 cells, mouse kidney tissue, mouse liver tissue, mouse ovary tissue |
| Positive IHC detected in | human cervical cancer |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with 12990-1-AP(PGRMC1 Antibody) at dilution of 1:1500
Immunohistochemistry of paraffin-embedded human cervical cancer using 12990-1-AP(PGRMC1 Antibody) at Dilution 1:100 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | PGRMC1 fusion protein ag3643 | Full name | progesterone receptor membrane component 1 |
|
Calculated molecular weight |
195aa,22kd |
Observed molecular
weight |
22kd |
|
GenBank accession number |
BC034238 | Gene ID (NCBI) | 10857 |
| Gene symbol | PGRMC1 | Synonyms | HPR6.6; MPR |
Background
Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297). |
