PRDX1 Antibody
Rabbit Polyclonal
Catalog number: 20568-1-AP
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Applications
| Tested applications | ELISA, WB, IF |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HeLa cells |
| Positive IF detected in | HepG2 cells |
| Recommended dilution | WB: 1:1000-1:10000 IF: 1:20-1:50 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HeLa cells were subjected to SDS PAGE followed by western blot with 20568-1-AP(PRDX1 Antibody) at dilution of 1:2000
Immunofluorescent analysis of HepG2 cells, using PRDX1 antibody 20568-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | peroxiredoxin 1 |
|
Calculated molecular weight |
22kd |
Observed molecular
weight |
23kd |
|
GenBank accession number |
NM_002574 | Gene ID (NCBI) | 5052 |
| Gene symbol | PRDX1 | Synonyms | MSP23; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2 |
Background
PRDX1, also named as PAGA, PAGB, TDPX2, PAG and NKEF-A, belongs to the ahpC/TSA family. It is involved in redox regulation of the cell. PRDX1 reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. PRDX1 plays an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. The antibody is specific to PRDX1. |
