RAD23A Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | mouse testis tissue |
| Recommended dilution | WB: 1:200-1:2000 |
IP = Immunoprecipitation
mouse testis tissue were subjected to SDS PAGE followed by western blot with 11364-1-AP(RAD23A Antibody) at dilution of 1:800
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | RAD23A fusion protein ag1907 | Full name | RAD23 homolog A (S. cerevisiae) |
|
Calculated molecular weight |
40kd |
Observed molecular
weight |
55kd |
|
GenBank accession number |
BC014026 | Gene ID (NCBI) | 5886 |
| Gene symbol | RAD23A | Synonyms | HHR23A; MGC111083 |
RAD23A, also named as HHR23A, belongs to the RAD23 family. It is a multiubiquitin chain receptor involved in modulation of proteasomal degradation. RAD23A binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. It is proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. It is involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. It is also involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages and is required for the association of HIV-1 vpr with the host proteasome. This antibody is a rabbit polyclonal antibody raised against full length RAD23A of human origin. |
