RIC8A Antibody
Rabbit Polyclonal
Catalog number: 18707-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | IHC |
| Species specificity | human; other species not tested. |
| Cited species | mouse |
| Positive WB detected in | human brain tissue |
| Recommended dilution | WB: 1:200-1:2000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
human brain tissue were subjected to SDS PAGE followed by western blot with 18707-1-AP(RIC8A Antibody) at dilution of 1:500
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) |
|
Calculated molecular weight |
60kd |
Observed molecular
weight |
60-70kd |
|
GenBank accession number |
BC011821 | Gene ID (NCBI) | 60626 |
| Gene symbol | RIC8A | Synonyms | MGC104517; MGC131931; MGC148073; MGC148074; RIC8; synembryn |
Background
RIC8, also named as RIC8A, is a Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. It is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8 also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. The antibody can recognize all these 3 isoforms of RIC8. |
