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  • KD/KO Validated

SDPR Polyclonal antibody

SDPR Polyclonal Antibody for IF, IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 12339-1-AP

Synonyms

Cavin 2, PS p68, SDPR, SDR



Tested Applications

Positive WB detected inA549 cells, mouse brain tissue, mouse liver tissue, COLO 320 cells, mouse placenta tissue, rat brain tissue, mouse heart tissue
Positive IP detected inmouse heart tissue
Positive IHC detected inhuman renal cell carcinoma tissue, human heart tissue, human tonsillitis tissue, human breast hyperplasia tissue, human kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inA549 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12339-1-AP targets SDPR in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SDPR fusion protein Ag2990
Full Name serum deprivation response (phosphatidylserine binding protein)
Calculated Molecular Weight 425 aa, 47 kDa
Observed Molecular Weight 68-70 kDa
GenBank Accession NumberBC016475
Gene Symbol SDPR
Gene ID (NCBI) 8436
RRIDAB_2183305
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Serum deprivation-response protein(SDRP), a substrate of protein kinase C, is a member of a group of proteins that bind to phosphatidylserine in a clacium-dependent manner. SDPR may participate in the generation or stabilization of membrane curvature. SDPR is highly expressed in heart and lung, and low in brain,kidney, liver, pancreas, placenta and skeletal muscle. This is a rabbit polyclonal anti-SDPR antibody raised against C-terminus of human SDPR. SDRP of molecular masses 115 kDa and 100 kDa were found in neutrophils, monocytes, lymphocytes, platelets and erythrocytes. In platelets, however, the principal SDRP is a cytosolic protein of molecular mass 68 kDa. (PMID: 2390065 )

Protocols

Product Specific Protocols
WB protocol for SDPR antibody 12339-1-APDownload protocol
IHC protocol for SDPR antibody 12339-1-APDownload protocol
IF protocol for SDPR antibody 12339-1-APDownload protocol
IP protocol for SDPR antibody 12339-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

ACS Nano

Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.

Authors - Zhiwei Liao
  • KD Validated
humanIF

Dev Cell

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq.

Authors - Nicole D Ulrich
mouseWB

Haematologica

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.

Authors - Nathan Eaton
mouseWB,IF,IP

Mol Metab

Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.

Authors - Yusuke Higuchi
ratIF

J Cereb Blood Flow Metab

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.

Authors - Margaret E Tome
humanWB,IHC

Cancer Cell Int

Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer.

Authors - Xiaoqing Luo