SETBP1 Antibody
Rabbit Polyclonal
Catalog number: 16841-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | SETBP1 fusion protein ag10532 | Full name | SET binding protein 1 |
|
Calculated molecular weight |
242aa,26kd |
Observed molecular
weight |
|
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GenBank accession number |
BC062338 | Gene ID (NCBI) | 26040 |
| Gene symbol | SETBP1 | Synonyms | DKFZp666J1210; KIAA0437; SEB |
Background
SETBP1 is initially found to interact with SET, which is a small protein inhibitor for tumor suppressors PP2A and NM23-H1. SET is fused with another gene CAN through chromosome translocation in a case of acute undifferentiated leukemia. SETBP1 may involve in chromosome translocation in a case of acute T-cell leukemia [PMID:17569777]. SETBP1 can cooperate with BCR/ABL to transform committed myeloid progenitors normally lacking self-renewal capability into LSCs and cause development of myeloid leukemias resembling human CML myeloid blast crisis [PMID:22566606]. SETBP1 was shown to form a complex with SET and PP2A, enhancing the stability of SET and its inhibition of PP2A. |
