SGSH Antibody
Rabbit Polyclonal
Catalog number: 14184-1-AP
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Applications
| Tested applications | ELISA, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive IHC detected in | human pancreas cancer |
| Recommended dilution | IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Immunohistochemistry of paraffin-embedded human pancreas cancer using 14184-1-AP(SGSH Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | SGSH fusion protein ag5435 | Full name | N-sulfoglucosamine sulfohydrolase |
|
Calculated molecular weight |
57kd |
Observed molecular
weight |
|
|
GenBank accession number |
BC047318 | Gene ID (NCBI) | 6448 |
| Gene symbol | SGSH | Synonyms | HSS; MPS3A; SFMD |
Background
SGSH(N-sulphoglucosamine sulphohydrolase) is also named as HSS, sulphamidase and belongs to the sulfatase family. Sulfamidase is synthesized as a 62 kDa precursor protein, which is modified with mannose 6-phosphate (M6P) residues, allowing their recognition by mannose-6-phosphate receptors in the Golgi complex and ensuring transport to the endosomal/lysosomal system(PMID:21671382). It catalyzes the third step of degradation of glucosaminoglycans and is required for the degradation of heparan sulphate. Defects in SGSH are the cause of mucopolysaccharidosis type 3A (MPS3A), also known as Sanfilippo syndrome A. This antibody is specific to SGSH. |
