SH2D1A Antibody
Rabbit Polyclonal
Catalog number: 11868-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | mouse thymus tissue |
| Recommended dilution | WB: 1:500-1:5000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse thymus tissue were subjected to SDS PAGE followed by western blot with 11868-1-AP(SH2D1A Antibody) at dilution of 1:1500
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | SH2D1A fusion protein ag2450 | Full name | SH2 domain protein 1A |
|
Calculated molecular weight |
128aa,14kd |
Observed molecular
weight |
16kd |
|
GenBank accession number |
BC020732 | Gene ID (NCBI) | 4068 |
| Gene symbol | SH2D1A | Synonyms | DSHP; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; XLP; XLPD |
Background
SH2D1A, also named as DSHP and SAP, is an inhibitor of the SLAM self-association. It acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. SH2D1A mediates interaction between FYN and SLAMF1. Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1). This antibody is specific to SH2D1A. |
