SKIV2L Antibody
Rabbit Polyclonal
Catalog number: 11462-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | human kidney tissue, HEK-293 cells |
| Recommended dilution | WB: 1:200-1:1000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
human kidney tissue were subjected to SDS PAGE followed by western blot with 11462-1-AP(SKIV2L Antibody) at dilution of 1:400
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | SKIV2L fusion protein ag1977 | Full name | superkiller viralicidic activity 2-like (S. cerevisiae) |
|
Calculated molecular weight |
1246aa,138kd |
Observed molecular
weight |
138kd |
|
GenBank accession number |
BC015758 | Gene ID (NCBI) | 6499 |
| Gene symbol | SKIV2L | Synonyms | 170A; DDX13; HLP; SKI2; SKI2W; SKIV2 |
Background
The Ski complex is a multiprotein complex required for exosome-mediated RNA surveillance, including the regulation of normal mRNA and the decay of nonfunctional mRNA. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) [PMID:22444670]. SKIV2L , one component of the Ski complex, acts as an RNA helicase with a role in exosome recruitment or activation. It is involved in the degradation of RNAs by the exosome and may have a role in autophagy [PMID:11719186]. |
