SPTBN1-Specific Antibody
Rabbit Polyclonal
Catalog number: 19722-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IHC, WB |
| Species specificity | human; other species not tested. |
| Cited species | human |
| Positive WB detected in | mouse brain tissue, mouse kidney tissue, mouse lung tissue |
| Positive IHC detected in | human lung |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with 19722-1-AP(SPTBN1-Specific Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung using 19722-1-AP(SPTBN1-Specific Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lung using 19722-1-AP(SPTBN1-Specific Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | spectrin, beta, non-erythrocytic 1 |
|
Calculated molecular weight |
275kd |
Observed molecular
weight |
275kd |
|
GenBank accession number |
NM_003128 | Gene ID (NCBI) | 6711 |
| Gene symbol | SPTBN1 | Synonyms | ELF; SPTB2; betaSpII |
Background
SPTBN1 is the non-erythrocytic form of β-spectrin or β-fodrin. Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. Reduced expression of SPTBN1 has been found to correlate with shorter survival of patients with hepatocellular cancer, pancreatic cancer and other malignancies of the gastrointestinal tract, suggesting tumor suppression ability of this protein. |
