SRC Antibody
Rabbit Polyclonal
Catalog number: 11097-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | A431 cells, CHO cells, COLO 320 cells, Jurkat cells, mouse brain tissue, SH-SY5Y cells |
| Positive IHC detected in | human breast cancer |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of anti-SRC (11097-1-AP for IP and Detection) with mouse spleen tissue lysate.
A431 cells were subjected to SDS PAGE followed by western blot with 11097-1-AP(SRC Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human breast cancer using 11097-1-AP(SRC Antibody) at Dilution 1:10 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | SRC fusion protein ag1575 | Full name | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
|
Calculated molecular weight |
60kd |
Observed molecular
weight |
55 kDa, 60 kDa |
|
GenBank accession number |
BC011566 | Gene ID (NCBI) | 6714 |
| Gene symbol | SRC | Synonyms | ASV; SRC1; c-SRC; p60-Src |
Background
SRC, also named as SRC1 and p60-Src, belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. It is a non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, SRC plays an important role in osteoclastic bone resorption. It promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. |
