SRPX2 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IHC |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | human placenta tissue, HepG2 cells, human brain tissue, human kidney tissue |
| Positive IHC detected in | human placenta |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
IP = Immunoprecipitation
human placenta tissue were subjected to SDS PAGE followed by western blot with 11845-1-AP(SRPX2 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human placenta using 11845-1-AP(SRPX2 Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human placenta using 11845-1-AP(SRPX2 Antibody) at Dilution 1:100 (under 40x lens)
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | SRPX2 fusion protein ag2516 | Full name | sushi-repeat-containing protein, X-linked 2 |
|
Calculated molecular weight |
465aa,53kd |
Observed molecular
weight |
53kd |
|
GenBank accession number |
BC020733 | Gene ID (NCBI) | 27286 |
| Gene symbol | SRPX2 | Synonyms | BPP; CBPS; PMGX; RESDX; SRPUL |
SRPX2 (sushi-repeat-containing protein, X-linked 2) is a secreted protein expressed in neurons of the human adult brain, including the rolandic area (PMID: 20874700). Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level, SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR, the urokinase-type plasminogen activator (uPA) receptor (PMID: 18718938). It is involved in seizure disorders, angiogenesis and cellular adhesion (PMID: 22242148; 19667118; 16497722). The involvement of SRPX2 in disorders of language cortex and cognition suggests it has an important role in the perisylvian region critical for language and cognitive development. (PMID: 16497722). |
