STK11 Antibody
Rabbit Polyclonal
Catalog number: 10746-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HEK-293 cells, Jurkat cells |
| Positive IHC detected in | human lymphoma |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with 10746-1-AP(STK11 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human lymphoma using 10746-1-AP(STK11 Antibody) at Dilution 1:50 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | STK11 fusion protein ag1048 | Full name | serine/threonine kinase 11 |
|
Calculated molecular weight |
49kd |
Observed molecular
weight |
54kd |
|
GenBank accession number |
BC007981 | Gene ID (NCBI) | 6794 |
| Gene symbol | STK11 | Synonyms | LKB1; PJS |
Background
STK11(serine/threonine-protein kinase 11) is also named as LKB1,PJS,and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response.The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS).Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers.This antibody is specific to STK11. |
