STMN3 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | mouse brain tissue, human brain tissue, rat brain tissue |
| Positive IHC detected in | human colon cancer |
| Recommended dilution | WB: 1:1000-1:10000 IHC: 1:20-1:200 |
IP = Immunoprecipitation
IP result of anti-STMN3 (11311-1-AP for IP and Detection) with mouse brain tissue lysate.
mouse brain tissue were subjected to SDS PAGE followed by western blot with 11311-1-AP(STMN3 Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human colon cancer using 11311-1-AP(STMN3 Antibody) at Dilution 1:50 (under 10x lens)
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | STMN3 fusion protein ag1853 | Full name | stathmin-like 3 |
|
Calculated molecular weight |
21kd |
Observed molecular
weight |
21-25kd |
|
GenBank accession number |
BC009381 | Gene ID (NCBI) | 50861 |
| Gene symbol | STMN3 | Synonyms | SCLIP |
Stathmin family phosphoproteins participate in the control of microtubule dynamics and have been proposed to be involved in the control of neuronal differentiation. Neuron specific Stathmin-3 (STMN3) is a novel STAT3 (signal transducer and activator of transcription 3) interacting protein. STAT3 is a key contributor to cancer cell migration and invasion. STMN3 exhibits microtubule-destabilizing activity, which is antagonized by STAT3. SCG10 is a widely studied and recognized neuronal differentiation marker, STMN3 is a SCG10-like protein (SCLIP) and is present from the earliest stages of hippocampal neuron differentiation in culture at vesicle-like structures following dynamic microtubules. RNAi mediated inhibition of this gene resulted in increased axonal branching. |
