XAB2 Antibody
Rabbit Polyclonal
Catalog number: 10637-1-AP
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Applications
| Tested applications | ELISA, WB |
| Cited applications | WB |
| Species specificity | human; other species not tested. |
| Cited species | human |
| Positive WB detected in | K-562 cells |
| Recommended dilution | WB: 1:200-1:1000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
K-562 cells were subjected to SDS PAGE followed by western blot with 10637-1-AP(XAB2 Antibody) at dilution of 1:200
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | XAB2 fusion protein ag0999 | Full name | XPA binding protein 2 |
|
Calculated molecular weight |
100kd |
Observed molecular
weight |
100kd |
|
GenBank accession number |
BC007208 | Gene ID (NCBI) | 56949 |
| Gene symbol | XAB2 | Synonyms | DKFZp762C1015; HCNP; HCRN; NTC90; SYF1 |
Background
XPA-binding protein 2 (XAB2) a tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. XAB2 is involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair, leading to preimplantation lethality, and is essential for mouse embryogenesis. It interactes with Cockayne syndrome groups A and B (CSA and CSB) proteins and RNA polymerase II, which are known to be involved in transcription-coupled repair (TCR) and transcription, and that the antibodies against XAB2 protein inhibited the recovery of RNA synthesis after UV irradiation and normal RNA synthesis when microinjected into living fibroblasts. |
