XRN2 Antibody
Rabbit Polyclonal
Catalog number: 11267-1-AP
Ask a question about this product click here
Loading price...
Applications
| Tested applications | ELISA, WB |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | HEK-293 cells, COLO 320 cells, HeLa cells |
| Recommended dilution | WB: 1:200-1:1000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with 11267-1-AP(XRN2 Antibody) at dilution of 1:300
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | XRN2 fusion protein ag1788 | Full name | 5'-3' exoribonuclease 2 |
|
Calculated molecular weight |
104kd |
Observed molecular
weight |
104kd |
|
GenBank accession number |
BC006417 | Gene ID (NCBI) | 22803 |
| Gene symbol | XRN2 | Synonyms |
Background
XRN2 is one exonuclease that degrades the Pol II associated product of poly(A) site cleavage, which is crucial for Pol II termination. During transcription termination, XRN2 cleavages at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. |
