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  • KD/KO Validated

YEATS2 Polyclonal antibody

YEATS2 Polyclonal Antibody for IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IP, IHC, ELISA

Conjugate

Unconjugated

Cat no : 24717-1-AP

Synonyms

KIAA1197, YEATS domain containing 2, YEATS2



Tested Applications

Positive WB detected inJurkat cells
Positive IP detected inJurkat cells
Positive IHC detected inhuman cervical cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

24717-1-AP targets YEATS2 in WB, IP, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen YEATS2 fusion protein Ag20134
Full Name YEATS domain containing 2
Calculated Molecular Weight 1422 aa, 151 kDa
Observed Molecular Weight 151 kDa
GenBank Accession NumberBC150273
Gene Symbol YEATS2
Gene ID (NCBI) 55689
RRIDAB_2879686
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

YEATS domain containing 2 (YEATS2) protein is a scaffolding subunit of the ATAC complex. Studies have shown that YEATS2 is a selective histone crotonylation reader and is related to histone acetylation. In addition, YEATS2 is associated with the progression of various tumors. Overexpression of YEATS2 promotes the proliferation and migration of pancreatic cancer cells. YEATS2 has been reported to be associated with the progression of non-small-cell lung cancer through histone acetylation.

Protocols

Product Specific Protocols
WB protocol for YEATS2 antibody 24717-1-APDownload protocol
IHC protocol for YEATS2 antibody 24717-1-APDownload protocol
IP protocol for YEATS2 antibody 24717-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Nat Commun

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

Authors - Wenyi Mi
  • KD Validated
humanWB,IHC,IP

Cell Biol Toxicol

YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.

Authors - Hao Sheng
  • KD Validated
humanWB,IHC

J Cell Physiol

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.

Authors - Zhirui Zeng
  • KD Validated
humanWB

Signal Transduct Target Ther

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.

Authors - Yiyi Xi
mouseWB,IHC

Phytomedicine

Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis

Authors - Tian Lan
humanWB

Cancers (Basel)

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway

Authors - Xin Liu