p70(S6K) Antibody
Rabbit Polyclonal
Catalog number: 14485-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HeLa cells, HepG2 cells, Jurkat cells |
| Positive IHC detected in | human breast cancer |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
-Antibody-14485-1-AP-p48029wb.jpg "HeLa cells were subjected to SDS PAGE followed by western blot with 14485-1-AP(p70(S6K) Antibody) at dilution of 1:1200")
HeLa cells were subjected to SDS PAGE followed by western blot with 14485-1-AP(p70(S6K) Antibody) at dilution of 1:1200-Antibody-14485-1-AP-IHC2735.jpg "Immunohistochemistry of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) Antibody) at Dilution 1:100 (under 10x lens)")
Immunohistochemistry of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) Antibody) at Dilution 1:100 (under 10x lens)-Antibody-14485-1-AP-IHC2736.jpg "Immunohistochemistry of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) Antibody) at Dilution 1:100 (under 40x lens)")
Immunohistochemistry of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) Antibody) at Dilution 1:100 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | p70(S6K) fusion protein ag5883 | Full name | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
|
Calculated molecular weight |
59kd |
Observed molecular
weight |
70kd,90kd |
|
GenBank accession number |
BC053365 | Gene ID (NCBI) | 6198 |
| Gene symbol | RPS6KB1 | Synonyms | PS6K; S6K; S6K1; STK14A; p70(S6K)-alpha; p70-S6K; p70-alpha |
Background
RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway and it plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy.(PMID:22684641). It has 2 isoforms produced by alternative initiation. This antibody is specific to p70(S6K). |
