PARK2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14060-1-AP

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Size: 09µ/gram

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, C6 cells, PC-12 cells, SH-SY5Y cells

Positive IHC detected in:
mouse brain tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Parkinson disease (autosomal recessive, juvenile) 2, parkin

Calculated molecular weight:
52 kDa

Observed molecular weight:
52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PARK2

Synonyms
AR JP, LPRS2, PARK2, Parkin, Parkinson disease protein 2, PDJ, PRKN
Background

Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin–protein ligase activity promotes the degradation of a viariety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson’s disease. It has 6 isoforms produced by alternative splicing.


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