REDD1 specific Antibody 123 Publications

Rabbit Polyclonal| Catalog number: 10638-1-AP

Featured Product Tested with siRNA

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Size: 09µ/gram

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Species specificity:
Human, Mouse, Rat

Positive WB detected in:
K-562 cells, A549 cells, DU 145 cells, LNCaP cells, MCF7 cells, PC-3 cells, Raji cells

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human kidney tissue, human breast cancer tissue, human gliomas tissue, human heart tissue, human liver tissue, human lung cancer tissue, human pancreas cancer tissue, human placenta tissue, human spleen tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

Immunogen Information


Full name:
DNA-damage-inducible transcript 4

Calculated molecular weight:
25 kDa

Observed molecular weight:
35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DDIT4

Synonyms
DDIT4, Dig2, FLJ20500, REDD 1, REDD1, RP11 442H21.1, RTP801
Background

REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family. REDD1 promotes neuronal cell death. It is a novel transcriptional target of p53 implicated ROS in the p53-dependent DNA damage response. REDD1 controlled cell growth under energy stress, as an essential regulator of TOR activity through the TSC1/2 complex. REDD-1 expression has also been linked to apoptosis, Aβ toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin[PMID: 19996311]. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level[PMID: 21733849]. REDD-1 negatively regulates the mammalian target of Rapamycin, a serine/threonine kinase often referred to as mTOR[PMID: 22951983]. It is crucial in the coupling of extra- and intracellular cues to mTOR regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness[PMID: 22304497]. REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy[PMID: 21909097]. The calculated molecular weight of REDD1 is 25 kDa. Because of multiple lysines in the proteins, REDD1 offen migrates around 35 kDa on Western blot[PMID: 19221489]. This antibody is a rabbit polyclonal antibody raised against full length human REDD1 antigen. This antibody is specific ti the REDD1 from siRNA experiment (PMID:24713927)


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