Vinculin Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66305-1-Ig |CloneNo.: 2B5A7

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Freight/Packing

Con: 117 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HeLa cells, pig heart tissue, rat heart tissue

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human prostate cancer tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vinculin

Calculated molecular weight:
1133aa,124 kDa

Observed molecular weight:
117 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VCL

Synonyms
CMD1W, Metavinculin, MVCL, VCL, Vinculin
Background

Vinculin belongs to the vinculin/alpha-catenin family. It is an actin filament (F-actin)-binding protein which involved in cell-matrix adhesion and cell-cell adhesion. Vinculin regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. It may also play important roles in cell morphology and locomotion. Vinculin is a 117-kDa, 1,066-amino-acid protein which is ubiquitously expressed. Its splice variant, metavinculin (124 kDa), is muscle-specific.


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