CBS Antibody
Rabbit Polyclonal
Catalog number: 14787-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IF |
| Cited applications | WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | mouse |
| Positive WB detected in | mouse kidney tissue, HeLa cells, mouse brain tissue, rat liver tissue |
| Positive IHC detected in | human pancreas cancer |
| Positive IF detected in | Hela cells |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:50-1:200 IF: 1:20-1:100 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
mouse kidney tissue were subjected to SDS PAGE followed by western blot with 14787-1-AP(CBS Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using 14787-1-AP(CBS Antibody) at Dilution 1:100 (under 10x lens)
Immunohistochemistry of paraffin-embedded human pancreas cancer using 14787-1-AP(CBS Antibody) at Dilution 1:100 (under 40x lens)
Immunofluorescent analysis of Hela cells, using CBS antibody 14787-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | CBS fusion protein ag6437 | Full name | cystathionine-beta-synthase |
|
Calculated molecular weight |
61kd |
Observed molecular
weight |
61kd |
|
GenBank accession number |
BC000440 | Gene ID (NCBI) | 875 |
| Gene symbol | CBS | Synonyms | HIP4 |
Background
The CBS gene encodes cystathionine beta-synthase, which catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity(PMID:11230183). CBS protein is localized in most areas of the brain, but predominantly in the cell bodies and neuronal processes of Purkinje cells and Ammon's horn neurons(PMID:12588964). This antibody is specific to CBS. |
