MET belongs to the protein kinase superfamily and Tyr protein kinase family. MET is a receptor for hepatocyte growth factor and scatter factor. MET has a tyrosine-protein kinase activity. MET functions in cell proliferation, scattering, morphogenesis and survival. It catalyzes the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Defects in MET may be associated with gastric cancer. Defects in MET are a cause of hepatocellular carcinoma (HCC). Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) which also known as papillary renal cell carcinoma 2 (RCCP2). Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9). c-Met is involved in cell migration and invasion, and is frequently up-regulated in cancer cells. In WB test, 160-170kd is the pro-MET,125kd and 145kd is mature MET,90kd is some other forms of MET.The antibody recognizes the N-term of MET.