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Applications
| Tested Applications: | ELISA,WB,IHC,IF |
| Specificity Reaction: | Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Positive WB detected In: | Hela cell,293 cell;A549 cell;BXPC-3 cell;COS7 cell;K562 cell;NIH3T3 cell;SH-SY5Y cell;HT1080 cell |
| Positive IHC detected In: | Ovary cancer |
| Positive IF detected In: | Hela |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Hela cell were subjected to SDS PAGE followed by western blot with 10526-1-AP(RRM1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Ovary cancer using 10526-1-AP(RRM1 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded Ovary cancer using 10526-1-AP(RRM1 Antibody) at Dilution 1:50 (under 40x lens)
Immunofluorescent analysis of Hela cells, using RRM1 antibody 10526-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Product Information
| Source: | Rabbit | Purify: | Antigen Affinity Purified |
| IsoType: | IgG | Storage: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | RRM1 fusion protein ag0789 | Full Name: | ribonucleotide reductase M1 |
|
Caculated Molecular Weight: |
90KD |
Observed Molecular
Weight: |
90kd |
| GenbankNo | BC006498 | GeneID: | 6240 |
| Symbol | RRM1 | Synonyms | RRM1;R1;RIR1;RR1 ; |
Background
Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B. RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells. Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival. |
