S100A11 Antibody
Rabbit Polyclonal
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | CoIP, IF, IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse |
| Positive WB detected in | PC-3 cells, HEK-293 cells, COLO 320 cells, human heart tissue, human lung tissue, DU 145 cells |
| Positive IHC detected in | human breast cancer |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
IP = Immunoprecipitation
IP result of anti-S100A11 (10237-1-AP) with PC-3 cell.
PC-3 cells were subjected to SDS PAGE followed by western blot with 10237-1-AP(S100A11 Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human breast cancer using 10237-1-AP(S100A11 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human breast cancer using 10237-1-AP(S100A11 Antibody) at Dilution 1:50 (under 40x lens)
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
| Immunogen | S100A11 fusion protein ag0343 | Full name | S100 calcium binding protein A11 |
|
Calculated molecular weight |
105aa,12kd |
Observed molecular
weight |
12kd |
|
GenBank accession number |
BC001410 | Gene ID (NCBI) | 6282 |
| Gene symbol | S100A11 | Synonyms | MLN70; S100C |
S100A11 (also known as S100C or calziggarin), is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs (PMID: 18694925). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. First discovered in 1989, S100A11 has since been proposed to have direct biological functions in an assortment of physiological processes such as endo- and exocytosis, regulation of enzyme activity, cell growth and regulation, apoptosis and inflammation (PMID: 15241500). Chromosomal rearrangements and altered expression of S100A11 have been implicated in tumor metastasis. This S100A11 antibody (10237-1-AP) has also been instrumental in investigations into S100A11’s role in the development of brain tumors in tuberous sclerosis complex (TSC) patients (PMID: 20133820). |
