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Applications
| Tested Applications: | ELISA,WB,IHC |
| Specificity Reaction: | Human; Other species are not tested.Please decide the specificity by homology |
| Positive WB detected In: | Raji cell |
| Positive IHC detected In: | H-brain |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Raji cell were subjected to SDS PAGE followed by western blot with 60154-1-Ig(SMN2 Antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded H-brain using 60154-1-Ig(SMN2 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded H-brain using 60154-1-Ig(SMN2 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source: | Mouse | Purify: | Protein A purified |
| IsoType: | IgG2a | Storage: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | SMN2 fusion protein ag14333 | Full Name: | survival of motor neuron 2, centromeric |
|
Caculated Molecular Weight: |
282aa,30kd |
Observed Molecular
Weight: |
38kd |
| GenbankNo | BC000908 | GeneID: | 6607 |
| Symbol | SMN2 | Synonyms | SMN2;BCD541;C-BCD541;FLJ76644;MGC20996;MGC5208;SMNC ;SMN1,SMN |
Background
The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-1-Ig is specific to Human SMN2. It can't recognize Mouse and Rat SMN gene. |
