VDAC1 Antibody
Rabbit Polyclonal
Catalog number: 10866-1-AP
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Applications
| Tested applications | ELISA, WB, IHC, IP |
| Cited applications | IF, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human, mouse, rat |
| Positive WB detected in | HEK-293 cells, HeLa cells, HL-60 cells, human heart tissue, Jurkat cells, mouse brain tissue, mouse heart tissue, mouse kidney tissue, DU 145 cells |
| Positive IHC detected in | human pancreas cancer |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
IP result of anti-VDAC1 (10866-1-AP with mouse skeletal muscle tissue lysate.).
HEK-293 cells were subjected to SDS PAGE followed by western blot with 10866-1-AP(VDAC1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas cancer using 10866-1-AP(VDAC1 Antibody) at Dilution 1:50 (under 10x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | VDAC1 fusion protein ag1144 | Full name | voltage-dependent anion channel 1 |
|
Calculated molecular weight |
31kd |
Observed molecular
weight |
31kd |
|
GenBank accession number |
BC008482 | Gene ID (NCBI) | 7416 |
| Gene symbol | VDAC1 | Synonyms | MGC111064; PORIN; PORIN-31-HL |
Background
VDAC1, also named as VDAC, Porin 31HM, Porin 31HL and Plasmalemmal porin, belongs to the eukaryotic mitochondrial porin family. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, to form a channel through the mitochondrial outer membrane and also the plasma membrane. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion. It is a 31kd membrane protein conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish. |
