VDAC1 Antibody
Rabbit Polyclonal
Catalog number: 55259-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | |
| Positive WB detected in | HepG2 cells, human skeletal muscle tissue, mouse liver tissue |
| Positive IHC detected in | human heart |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HepG2 cells were subjected to SDS PAGE followed by western blot with 55259-1-AP(VDAC1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human heart using 55259-1-AP(VDAC1 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human heart using 55259-1-AP(VDAC1 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | voltage-dependent anion channel 1 |
|
Calculated molecular weight |
31kd |
Observed molecular
weight |
31-33kd |
|
GenBank accession number |
NM_003374 | Gene ID (NCBI) | 7416 |
| Gene symbol | VDAC1 | Synonyms | MGC111064; PORIN; PORIN-31-HL |
Background
VDAC1, also named as VDAC, Porin 31HM, Porin 31HL and Plasmalemmal porin, belongs to the eukaryotic mitochondrial porin family. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, to form a channel through the mitochondrial outer membrane and also the plasma membrane. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion. It is a 31kd membrane protein conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish. This antibody is specific to VDAC1. |
